The Role of Stress in Abdominal Pain

The role of stress in abdominal pain is well documented across gastroenterology and behavioral medicine. Psychological stress activates the brain–gut axis, increasing visceral hypersensitivity, altering gut motility, and promoting inflammation. These mechanisms can exacerbate functional disorders such as irritable bowel syndrome, leading to cramping, bloating, and discomfort without clear structural disease. Chronic stress also affects immune response and gut microbiota, further contributing to persistent pain. While pharmacologic treatments target specific causes, stress management through cognitive behavioral therapy, relaxation techniques, and lifestyle modification is essential. For providers working with a mebendazole wholesaler, patient education should emphasize that medication alone is insufficient.